ABSTRACT
<p><b>OBJECTIVE</b>To analyze the effect of lymphocyte/monocyte ratio(LMR) on clinical features and prognosis of patients with primary gastrointestinal diffuse large B cell lymphoma(PGI-DLBCL).</p><p><b>METHODS</b>The clinical data of 38 PGI-DLBCL patients with complete follow-up data in our hospital were analyzed retrospectively. The absolute lymphocyte count(ALC), absolute monocyte count(AMC) and LMR were counted by automating complete blood cell count statistics in newly diagnosed patients, and then the LMR cut off value was obtained by ROC curve. All patients were divided into ≤3.9 group and >3.9 group according to cut off value.</p><p><b>RESULTS</b>Out of 38 patients 21 male and 17 female with a median age 55 old years (29-73 years), 7 cases died, the clinical B symptom occurred in 7 cases (18.4%); the pathologic type of 13 cases (34.2%) belonged to germinal center B-cell like, the primary gastral and intestinal DLBCL were observed in 18 and 20 cases respectively. The chisquare test showed that the LMR associated with of clinical stage and tumor size of PGI-DLBCL. The median survival time was 44 months (7-100 months), and 5-year overrall survival(OS) rate was 78.3% for 38 PGI-DLBCL cases. The univariate analysis showed that age (P=0.021), stage (P=0.012), IPI score (P=0.001), LDH level (P<0.001), tumor size (P=0.037) and LMR (P=0.026) all associate with the 5 years OS rate(%), and the difference was between them statistically significant, but the multivariate analysis showed that only clinical staging is independent risk factors for the OS.</p><p><b>CONCLUSION</b>LMR shows an important effect on clinical features and prognosis of PGI-DLBCL.</p>
ABSTRACT
<p><b>OBJECTIVE</b>To study the clinical and laboratory features and diagnosis of the patient with anti-N-methyl-D-aspartate receptor(NMDAR)encephalitis in children.</p><p><b>METHOD</b>The data of clinical feature, laboratory findings, and radiological manifestation were reviewed and analyzed.</p><p><b>RESULT</b>Of the 7 patients, 4 were female and 3 were male. The age of onset was from 6.6 to 15.5 years (average 9.5 years). The onset of 4 cases started with convulsion. Six cases had seizures which was difficult to control by antiepileptic drugs. All patients had psychiatric symptoms and speech disorder. Six cases had different levels of decreased consciousness and dyskinesias. 6 cases had autonomic nerve instability, and 7 cases developed sleep disorders. The results of MRI examination were normal in all patients. The EEG of most patients showed focal or diffuse slow waves. Six cases had oligoclonal bands. All cases were confirmed to have the disease by detection of anti-NMDA receptor antibodies. No tumor was detected in any of the patients. All patients received immunotherapy.</p><p><b>CONCLUSION</b>Anti-NMDAR encephalitis is a severe but treatable disorder that frequently affects children and adolescents. Pediatric patients had clinical manifestations similar to those of adult patients. But children have a lower incidence of tumors and hypoventilation also occurs less frequently in children. Most of children had a good prognosis.</p>